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Retatrutide vs Semaglutide
These two sit at opposite ends of the incretin spectrum. Semaglutide is a single GLP-1 receptor agonist; retatrutide is a triple agonist targeting GLP-1, GIP, and glucagon receptors. Here is how the newest and the most-established incretin peptides compare.
Retatrutide
Triple agonist — GLP-1 / GIP / glucagon
Triple incretin agonist — the newest and broadest of the three, still investigational.
View Retatrutide →Semaglutide
Single agonist — GLP-1
Single GLP-1 receptor agonist — the most established of the three.
View Semaglutide →Side by side
| Retatrutide | Semaglutide | |
|---|---|---|
| Receptor targets | GLP-1, GIP, and glucagon (GCG) receptors | The GLP-1 receptor only |
| Mechanism class | Triple incretin agonist — the newest and broadest of the three, still investigational. | Single GLP-1 receptor agonist — the most established of the three. |
| Typical research cadence | Once-weekly subcutaneous in most research protocols. | Once-weekly subcutaneous in most research protocols. |
| Approx. half-life | ~6 days (supports weekly dosing) | ~7 days (supports weekly dosing) |
| Domain | Metabolic | Metabolic |
The short version
Retatrutide (triple agonist) and semaglutide (single GLP-1) are the widest mechanistic contrast in the incretin class. Both are weekly peptides handled the same way in the lab; the receptor breadth is the variable that matters for a research protocol.
Dosage calculator
Convert any target dose into exact syringe units for your vial.
Lab testing & COAs
How every lot is verified — third-party HPLC, ≥98% purity.
Protocols
Goal-oriented stacks mapped to specific compounds.
Frequently asked questions
What is the difference between retatrutide and semaglutide?
Semaglutide targets one receptor (GLP-1). Retatrutide targets three (GLP-1, GIP, and glucagon), making it a triple agonist. Retatrutide is investigational and the newest of the incretin peptides; semaglutide is the most established.
Are they dosed differently?
Both are weekly subcutaneous peptides in most research protocols, but milligram amounts differ. The dosage calculator converts any target dose into syringe units for your specific vial.
Disclaimer
This comparison describes receptor mechanism and handling for research context only. It is not medical advice and makes no claim of safety or efficacy. All compounds are sold for research use only. Consult a licensed physician before using any peptide compound outside controlled research.