Stacking

Stacking is the informal term for combining two or more compounds in one protocol. In the research literature the practice has a specific rationale: two compounds acting through different mechanisms on the same outcome may be additive or synergistic. The classic example is a GHRH analogue such as CJC-1295 with a ghrelin receptor agonist such as ipamorelin: the two receptors act on the pituitary through separate pathways, and studies in humans have shown the combination releases more growth hormone than either alone.

The honest caveat is that most stacks are not studied as stacks. BPC-157 and TB-500 are paired constantly because their mechanisms are complementary, but no controlled trial has tested the pair against either compound alone. Blends such as GLOW and KLOW exist because researchers ask for the combination, not because the combination has its own evidence base. Each profile's "Interactions and stacking" section says which pairings have data and which are inference.

For handling, a blend changes the reconstitution arithmetic because each component has its own concentration in the shared solution. The stacking fundamentals guide covers both the logic and the math.