The longevity domain has the most mechanistic breadth of any NeuroForge category. The compounds below don't share a single pathway — they address growth-hormone output, mitochondrial coenzyme supply, and circadian regulation independently — which is what makes them additive rather than redundant.
This is a layered protocol. Any one compound runs meaningfully on its own; running all three addresses three distinct aging signals simultaneously.
Core compound — CJC-1295 + Ipamorelin blend
NF-022 (CJC-1295 + Ipamorelin) is the standard synergistic GH secretagogue pair. CJC-1295 is a GHRH analog — upstream, sustained release. Ipamorelin is a selective GH secretagogue — downstream, pulsatile. They bind different receptors and produce a GH pulse larger than either alone.
The combination blend is dosed once or twice daily subq. Morning and pre-bed are the published windows that respect endogenous rhythm.
Mitochondrial substrate — NAD+
NAD+ (NF-007) supplies the precursor molecule for mitochondrial electron transport, sirtuin activity, and DNA repair. The IV literature is stronger than the subcutaneous literature, but subq dosing has a cleaner protocol and fewer logistical barriers.
A 100–300 mg weekly subq dose is the research-range equivalent to a standard infusion protocol. Expect flushing and warmth during administration — both are normal and subside within 15 minutes.
Circadian peptide — Epithalon
Epithalon (NF-010) is a four-amino-acid synthetic analog of a pineal-derived peptide. The Russian literature associates it with telomerase activation and normalization of circadian melatonin output in older subjects. Cycled — typically 10 days on, several months off — rather than run continuously.
Proposed dosing window
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