Oestrogen-related receptor agonist
SLU-PP-332 in Canada
Also known as SLU PP 332 · SLUPP-332 · Pan-ERR agonist · ERRα agonist SLU-PP-332
SLU-PP-332 is not a peptide. It is a synthetic small molecule that activates the three oestrogen-related receptors — orphan nuclear receptors that switch on the genes for mitochondrial biogenesis and fatty-acid oxidation in muscle — and it became widely known in 2023 when two papers from one laboratory reported that it made mice run further and lose fat. That is the entire evidence base: mouse studies from the group that designed it, no human pharmacokinetics, no human safety data and no clinical trial anywhere. Canada Peptides carries research-grade SLU-PP-332, priced and shipped in CAD for laboratory and research use only.
Quick facts
- Class
- Synthetic small molecule; pan-agonist of ERRα, ERRβ and ERRγ (nuclear receptors NR3B1–3)
- Structure
- Small synthetic organic molecule of a few hundred daltons; structure disclosed in the 2023 papers · not a peptide
- Half-life
- Short in mice — on the order of hours — which is why the studies dosed twice daily; no human data
- Route in research
- Intraperitoneal injection in a DMSO-containing vehicle in every published study
- Cadence in research
- Twice daily for two to four weeks in the mouse studies
- Storage
- Dry powder: cool, dry, dark, tightly sealed; stock solutions in DMSO frozen in aliquots
- Status in Canada
- No Health Canada market authorisation or DIN; never reviewed by any regulator. Research use only
